In a statement on Friday night, Mali's government confirmed the death of the girl, who has not been identified.
"In this moment of sadness, the government would like to express its condolences to her family and reminds the population that maintain very strict hygiene rules remains the best way to contain this disease," it said.
The worst Ebola outbreak on record has killed 4,900 and also more than 10,000 cases, mainly in nearby Liberia, Sierra Leone and Guinea.
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